Population pharmacokinetics of sonidegib (LDE225), an oral inhibitor of hedgehog pathway signaling, in healthy subjects and in patients with advanced solid tumors-Reference-Cited by-同舟云学术

Population pharmacokinetics of sonidegib (LDE225), an oral inhibitor of hedgehog pathway signaling, in healthy subjects and in patients with advanced solid tumors

Published:2016-02-22 Issue:4 Volume:77 Page:745-755
ISSN:0344-5704
Container-title:Cancer Chemotherapy and Pharmacology
language:en
Short-container-title:Cancer Chemother Pharmacol

Author:

Goel Varun,Hurh Eunju,Stein Andrew,Nedelman Jerry,Zhou Jocelyn,Chiparus Ovidiu,Huang Pai-Hsi,Gogov Sven,Sellami Dalila

Funder

Novartis Pharmaceuticals Corporation

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s00280-016-2982-1.pdf

Reference19 articles.

1. di Magliano MP, Hebrok M (2003) Hedgehog signaling in cancer formation and maintenance. Nat Rev Cancer 3(12):903–911

2. McMahon AP, Ingham PW, Tabin CJ (2003) Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 53:1–114

3. Teglund S, Toftgard R (2010) Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 1805(2):181–208

4. Pan S et al (2010) Discovery of NVP-LDE225, a potent and selective smoothened antagonist. ACS Med Chem Lett 1(3):130–134

5. Buonamici S et al (2010) Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2(51):5170

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