Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma-Reference-Cited by-同舟云学术

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Published:2010-09-29 Issue:51 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Buonamici Silvia¹,Williams Juliet¹,Morrissey Michael¹,Wang Anlai¹,Guo Ribo¹,Vattay Anthony¹,Hsiao Kathy¹,Yuan Jing¹,Green John¹,Ospina Beatriz¹,Yu Qunyan¹,Ostrom Lance¹,Fordjour Paul¹,Anderson Dustin L.¹,Monahan John E.¹,Kelleher Joseph F.¹,Peukert Stefan¹,Pan Shifeng²,Wu Xu²,Maira Sauveur-Michel³,García-Echeverría Carlos³,Briggs Kimberly J.⁴,Watkins D. Neil⁵,Yao Yung-mae¹,Lengauer Christoph¹,Warmuth Markus¹,Sellers William R.¹,Dorsch Marion¹

Affiliation:

1. Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

2. Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

3. Novartis Institutes for Biomedical Research, 4057 Basel, Switzerland.

4. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.

5. Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.

Abstract

Resistance of medulloblastoma to Smo antagonists can be delayed or prevented by specific drug combinations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference27 articles.

1. Hedgehog: functions and mechanisms

2. Hedgehog beyond medulloblastoma and basal cell carcinoma.;Teglund S.;Biochim. Biophys. Acta,2010

3. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice

4. Acquired resistance to tyrosine kinase inhibitors during cancer therapy

5. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Cited by 417 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Interactions between hedgehog signaling pathway and the complex tumor microenvironment in breast cancer: current knowledge and therapeutic promises;Cell Communication and Signaling;2024-09-09

2. A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma;Cell Reports;2024-08

3. A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened;Cell Chemical Biology;2024-07

4. Targeting Super-Enhancer–Driven Transcriptional Dependencies Suppresses Aberrant Hedgehog Pathway Activation and Overcomes Smoothened Inhibitor Resistance;Cancer Research;2024-05-22

5. Plasma ctDNA Monitoring of a PTCH1-Mutant Metastatic Adult Medulloblastoma Showing a Durable Benefit With Vismodegib;The Oncologist;2024-03-04