Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Author:
Affiliation:
1. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121
2. Novartis Institute for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml1000307
Reference20 articles.
1. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
2. 1 Developmental roles and clinical significance of Hedgehog signaling
3. Hedgehog signaling in animal development: paradigms and principles
4. Hedgehog signalling in cancer formation and maintenance
5. Targeting the Hedgehog pathway in cancer
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