Reprogramming Halomonas for industrial production of chemicals-Reference-Cited by-同舟云学术

Reprogramming Halomonas for industrial production of chemicals

Published:2018-07-01 Issue:7 Volume:45 Page:545-554
ISSN:1476-5535
Container-title:Journal of Industrial Microbiology and Biotechnology
language:en
Short-container-title:

Author:

Chen Xiangbin¹²³,Yu Linping¹²³,Qiao Guanqing¹²³,Chen Guo-Qiang¹²³⁴

Affiliation:

1. 0000 0001 0662 3178 grid.12527.33 MOE Lab of Bioinformatics, School of Life Sciences Tsinghua University 100084 Beijing China

2. 0000 0001 0662 3178 grid.12527.33 Center for Synthetic and Systems Biology Tsinghua University 100084 Beijing China

3. 0000 0001 0662 3178 grid.12527.33 Tsinghua-Peking Center for Life Sciences Tsinghua University 100084 Beijing China

4. 0000000121662407 grid.5379.8 Manchester Institute of Biotechnology, Centre for Synthetic Biology The University of Manchester 131 Princess Street M1 7DN Manchester UK

Abstract

Abstract Halomonas spp. are able to grow under a high salt concentration at alkali pH, they are able to resist contamination by other microbes. Development of Halomonas spp. as platform production strains for the next-generation industrial biotechnology (NGIB) is intensively studied. Among Halomonas spp., Halomonas bluephagenesis is the best studied one with available engineering tools and methods to reprogram it for production of various polyhydroxyalkanoates, proteins, and chemicals. Due to its contamination resistance, H. bluephagenesis can be grown under open and continuous processes not just in the labs but also in at least 1000 L fermentor scale. It is expected that NGIB based on Halomonas spp. be able to engineer for production of increasing number of products in a competitive manner.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Applied Microbiology and Biotechnology,Biotechnology,Bioengineering

Link

http://link.springer.com/article/10.1007/s10295-018-2055-z/fulltext.html

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