Affiliation:
1. 0000 0001 2181 7878 grid.47840.3f Department of Chemical and Biomolecular Engineering University of California Berkeley Berkeley CA USA
2. 0000 0001 2181 7878 grid.47840.3f Department of Plant and Microbial Biology University of California Berkeley Berkeley CA USA
3. Chan Zuckerberg Biohub San Francisco CA USA
Abstract
Abstract
Natural product discovery in the microbial world has historically been biased toward aerobes. Recent in silico analysis demonstrates that genomes of anaerobes encode unexpected biosynthetic potential for natural products, however, chemical data on natural products from the anaerobic world are extremely limited. Here, we review the current body of work on natural products isolated from strictly anaerobic microbes, including recent genome mining efforts to discover polyketides and non-ribosomal peptides from anaerobes. These known natural products of anaerobes have demonstrated interesting molecular scaffolds, biosynthetic logic, and/or biological activities, making anaerobes a promising reservoir for future natural product discovery.
Funder
National Center for Complementary and Alternative Medicine
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology,Biotechnology,Bioengineering
Cited by
24 articles.
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