Use of Isotopes and LC-MS-ESI-TOF for Mechanistic Studies of Tienilic Acid Metabolic Activation-Reference-Cited by-同舟云学术

Use of Isotopes and LC-MS-ESI-TOF for Mechanistic Studies of Tienilic Acid Metabolic Activation

Published:2001 Issue: Volume: Page:139-144
ISSN:0065-2598
Container-title:Advances in Experimental Medicine and Biology
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Author:

Belghazi Maya,Jean Pascale,Poli Sonia,Schmitter Jean-Marie,Mansuy Daniel,Dansette M. Patrick

Publisher

Springer US

Link

http://link.springer.com/content/pdf/10.1007/978-1-4615-0667-6_17.pdf

Reference5 articles.

1. Bonierbale E., Valadon P., Pons C., Desfosses B., Dansette P. M. and Mansuy D. (1999), Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: Use of specific antitienilic acidprotein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds, Chem Res Toxicol, 12, 286–296. and references therein.

2. Jean Pascale, (1997) Mécanisme de l’inhibition des cytochromes P450 par les 2-aroylthiophenes et modèlisation molèculaire. Thèse de l’ Université Paris 5.

3. Koenigs L. L., Peter R. M., Hunter A. P., Haining R. L., Rettie A. E., Friedberg T., Pritchard M. P., Shou M., Rushmore T. H. and Trager W. F. (1999), Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9, Biochemistry, 38, 2312–2319.

4. Lopezgarcia M. P., Dansette P. M. and Mansuy D. (1994), Thiophene Derivatives as New Mechanism-Based Inhibitors of Cytochrome-P-450 - Inactivation of Yeast-Expressed Human Liver Cytochrome-P-450–2C9 by Tienilic Acid, Biochemistry, 33, 166–175.

5. Valadon P., Dansette P. M., Girault J. P., Amar C. and Mansuy D. (1996), Thiophene sulfoxides as reactive metabolites: Formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo, Chem Res Toxicol, 9, 1403–1413.

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