Further Assessment of the Relay Hepatocyte Assay for Determination of Intrinsic Clearance of Slowly Metabolised Compounds Using Radioactivity Monitoring and LC–MS Methods
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology
Link
http://link.springer.com/content/pdf/10.1007/s13318-019-00571-x.pdf
Reference20 articles.
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3. Bonn B, Svanberg P, Janefeldt A, Hultman LA, Grime K. Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: comparison of a primary hepatocyte/stromal cell-co-culture with plated primary hepatocytes and HepaRG. Drug Metab Disp. 2016;44:527–33. https://doi.org/10.1124/dmd.115.067769 .
4. Di L, Obach S. Addressing challenges of low clearance in drug research. AAPS J. 2015;17(2):352–7. https://doi.org/10.1208/s12248-014-9691-7 .
5. Zanelli U, Michna T, Petersson C. Determination of low intrinsic clearance in vitro: the benefit of a novel internal standard in human hepatocyte incubations. Xenobiotica. 2018;49(4):381–7. https://doi.org/10.1080/00498254.2018.1451010 .
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