Protein binding of brequinar in the plasma of healthy donors and cancer patients and analysis of the relationship between protein binding and pharmacokinetics in cancer patients-Reference-Cited by-同舟云学术

Protein binding of brequinar in the plasma of healthy donors and cancer patients and analysis of the relationship between protein binding and pharmacokinetics in cancer patients

Published:1994-03 Issue:2 Volume:35 Page:101-108
ISSN:0344-5704
Container-title:Cancer Chemotherapy and Pharmacology
language:en
Short-container-title:Cancer Chemother. Pharmacol.

Author:

King Shang-Ying P.,Agra Allison M.,Shen Huey-Shin L.,Chi Cecilia L.,Adams David B.,Currie Violante E.,Bertino Joseph R.,Pieniaszek Henry J.,Quon Check Y.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/BF00686630.pdf

Reference28 articles.

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2. Abramson FP, Jenkins J, Ostchega Y (1982) Effects of cancer and its treatments on plasma concentration of α1-acid glycoprotein and propranolol binding. Clin Pharmacol Ther 32:659

3. Arteaga CL, Brown TD, Kuhn JG, Shen HSL, O'Rourke TJ, Beougher K, Brentzel HJ, Von Hoff DD, Weiss GR (1989) Phase I clinical and pharmacokinetic trial of brequinar sodium (DuP 785, NSC 368390). Cancer Res 49:4648

4. Aungst BJ, Blake JA, Rogers NJ, Dusak BA (1990) Effects of plasma protein binding displacement on the pharmacokinetics, tissue and tumor concentrations, and efficacy of brequinar, a highly protein-bound antitumor agent. J Pharmacol Exp Ther 253:230

5. Bischoff KB, Dedrick RL, Zaharko DS, Longstreth JA (1971) Methotrexate pharmacokinetics. J Pharm Sci 60:1128

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