Author:
Mohammadinejad Reza,Ashrafizadeh Milad,Pardakhty Abbas,Uzieliene Ilona,Denkovskij Jaroslav,Bernotiene Eiva,Janssen Lauriane,Lorite Gabriela S.,Saarakkala Simo,Mobasheri Ali
Abstract
Abstract
Purpose of Review
In this review article, we discuss the potential for employing nanotechnological strategies for the diagnosis, monitoring, and clinical management of osteoarthritis (OA) and explore how nanotechnology is being integrated rapidly into regenerative medicine for OA and related osteoarticular disorders.
Recent Findings
We review recent advances in this rapidly emerging field and discuss future opportunities for innovations in enhanced diagnosis, prognosis, and treatment of OA and other osteoarticular disorders, the smart delivery of drugs and biological agents, and the development of biomimetic regenerative platforms to support cell and gene therapies for arresting OA and promoting cartilage and bone repair.
Summary
Nanotubes, magnetic nanoparticles, and other nanotechnology-based drug and gene delivery systems may be used for targeting molecular pathways and pathogenic mechanisms involved in OA development. Nanocomposites are also being explored as potential tools for promoting cartilage repair. Nanotechnology platforms may be combined with cell, gene, and biological therapies for the development of a new generation of future OA therapeutics.
Funder
University of Oulu including Oulu University Hospital
Publisher
Springer Science and Business Media LLC
Cited by
44 articles.
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