Future nanomedicine for the diagnosis and treatment of osteoarthritis

Author:

Eichaker Lauren R12,Cho Hongsik12,Duvall Craig L3,Werfel Thomas A3,Hasty Karen A12

Affiliation:

1. Department of Biomedical Engineering & Orthopaedic Surgery/Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA

2. Research Service 151, VA Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA

3. Department of Biomedical Engineering, Vanderbilt University, VU Station B 351631, Nashville, TN 37235-1631, USA

Abstract

Current treatments for osteoarthritis (OA) are largely palliative until the joints become totally dysfunctional and prosthetic replacement becomes necessary. Effective methods are needed for diagnosing OA and monitoring its progression during its early stages, when the effects of therapeutic drugs or biological agents are most likely to be effective. Theranostic nanosomes and nanoparticles have the potential to noninvasively detect, track and treat the early stages of OA. As articular cartilage does not regenerate once it is degraded, cell-based treatments aided by superparamagnetic iron oxide nanoparticle tracking are attractive future treatment modalities for the later stages of OA progression, when significant cartilage replacement is needed. This article will describe the current and future translational approaches for the detection and noninvasive treatment of degenerative OA.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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