Affiliation:
1. School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USA
Abstract
Administration through the respiratory tract can be advantageous, with high drug bioavailability, limited enzymatic activity, reduced dose requirements compared to oral, and potentially diminished side effects. Among the different types of drugs studied for pulmonary delivery, genetic material delivery has gained favorable scientific interest, using polymer-, lipid-, inorganic-, or vector-based nanocarriers. As pulmonary drug delivery has been associated with challenges, including physiological barriers and lung metabolism, the delivery of sensitive molecules such as nucleic acids can exacerbate these challenges. While short-interfering RNAs (siRNAs) have been extensively reported as suitable ribonucleic acid interference (RNAi) candidates for pulmonary delivery, discussion on micro-RNA (miR) pulmonary delivery is limited despite their significant therapeutic potential. Recently, these non-coding RNAs have been explored in targeted or non-targeted pulmonary administration against various diseases. This review addresses the information gap on miR-pulmonary delivery with updated and concentrated literature. We briefly discuss the barriers to lung administration, describe different functional nanocarriers for miR delivery, and provide an extensive literature update on the different miRs and their targeted diseases currently being studied.
Funder
Research Competitiveness Subprogram (RCS) of the Louisiana Board of Regents through the Board of Regents Support Fund
National Institutes of Health (NIH) through the National Institute of General Medical Science
Subject
Process Chemistry and Technology,Chemical Engineering (miscellaneous),Bioengineering
Reference213 articles.
1. Chaurasiya, B., and Zhao, Y.Y. (2020). Dry Powder for Pulmonary Delivery: A Comprehensive Review. Pharmaceutics, 13.
2. Comparing clinical features of the nebulizer, metered-dose inhaler, and dry powder inhaler;Geller;Respir. Care,2005
3. Comprehensive literature review on COVID-19 vaccines and role of SARS-CoV-2 variants in the pandemic;Yap;Ther. Adv. Vaccines Immunother.,2021
4. Lipid nanoparticles for mRNA delivery;Hou;Nat. Rev. Mater.,2021
5. Thi, T.T.H., Suys, E.J.A., Lee, J.S., Nguyen, D.H., Park, K.D., and Truong, N.P. (2021). Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines. Vaccines, 9.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献