Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity-Reference-Cited by-同舟云学术

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Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

Published:2011-11-22 Issue:5 Volume:90 Page:575-585
ISSN:0946-2716
Container-title:Journal of Molecular Medicine
language:en
Short-container-title:J Mol Med

Author:

Yang Shi-Bing,Lee Hye Young,Young David Matthew,Tien An-Chi,Rowson-Baldwin Ashley,Shu Yu Yu,Jan Yuh Nung,Jan Lily Yeh

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Drug Discovery,Molecular Medicine

Link

http://www.springerlink.com/index/pdf/10.1007/s00109-011-0834-3

Reference35 articles.

1. Wullschleger S, Loewith R, Oppliger W, Hall MN (2005) Molecular organization of target of rapamycin complex 2. J Biol Chem 280:30697–30704

2. Boura-Halfon S, Zick Y (2009) Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 296:E581–E591

3. Tsang CK, Qi H, Liu LF, Zheng XF (2007) Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 12:112–124

4. Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer’s disease. PLoS One 5:e9979

5. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS et al (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392–395

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