Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks

Author:

Lee Jung Dae,Bae Jin-Sook,Kim Hyang Yeon,Song Si-Whan,Kim Jong-Choon,Lee Byung-Mu,Kim Kyu-BongORCID

Funder

Ministry of Food and Drug Safety

Publisher

Springer Science and Business Media LLC

Reference46 articles.

1. Anderson JM, Rodriguez A, Chang DT (2008) Foreign body reaction to biomaterials. Semin Immunol 20:86–100

2. Aubert N, Ameller T, Legrand JJ (2012) Systemic exposure to parabens: pharmacokinetics, tissue distribution, excretion balance and plasma metabolites of [14C]-methyl-, propyl- and butylparaben in rats after oral, topical or subcutaneous administration. Food Chem Toxicol 50:445–454

3. Bae JS, Lee JD, Song SW (2021) Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats. Arch Toxicol 95:2037–2050

4. Cashman AL, Warshaw EM (2005) Parabens: a review of epidemiology, structure, allergenicity, and hormonal properties. Dermatitis 16:57–66

5. CIR (Cosmetic Ingredient Review) (2008) Report on the safety assessment of methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, and benzylparaben as used in cosmetic products. Int J Toxicol 27(Suppl 4):1–82

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