Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system-Reference-Cited by-同舟云学术

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Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system

Published:2021-10-16 Issue: Volume: Page:
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Negoro Ryosuke^ORCID,Yamada Naoki,Watanabe Keita,Kono Yusuke,Fujita Takuya

Funder

japan society for the promotion of science

japan agency for medical research and development

nakatomi foundation

promotion and mutual aid corporation for private schools of japan

ritsumeikan university

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00204-021-03175-0.pdf

Reference39 articles.

1. Balimane PV, Chong S (2005) Cell culture-based models for intestinal permeability: a critique. Drug Discov Today 10:335–343. https://doi.org/10.1016/S1359-6446(04)03354-9

2. Cheng L, Li M, Hu J et al (2014) UGT1A1*6 polymorphisms are correlated with irinotecan-induced toxicity: a system review and meta-analysis in Asians. Cancer Chemother Pharmacol 73:551–560. https://doi.org/10.1007/s00280-014-2382-3

3. Crespi CL, Bruce W, Penman MH (1996) Development of Caco-2 cells expressing high levels of cDNA derived CYP3A4.pdf. Pharm Res 13:1635–1641

4. Cummins CL, Mangravite LM, Benet LZ (2001) Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharm Res 18:1102–1109. https://doi.org/10.1023/A:1010914624111

5. Cummins CL, Jacobsen W, Christians U, Benet LZ (2004) CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther 308:143–155. https://doi.org/10.1124/jpet.103.058065

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4. 5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells;Biochemical and Biophysical Research Communications;2023-07

5. Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system;Drug Metabolism and Pharmacokinetics;2023-06

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