Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System-Reference-Cited by-同舟云学术

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Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System

Published:2024-08-08 Issue:8 Volume:47 Page:1422-1428
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biological & Pharmaceutical Bulletin

Author:

Negoro Ryosuke¹,Ouchi Ayu¹,Deguchi Sayaka²,Takayama Kazuo²³,Fujita Takuya¹⁴

Affiliation:

1. Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University

2. Center for iPS Cell Research and Application (CiRA), Kyoto University

3. AMED-CREST, AMED

4. Research Center for Drug Discovery and Development, Ritsumeikan University

Publisher

Pharmaceutical Society of Japan

Link

https://www.jstage.jst.go.jp/article/bpb/47/8/47_b24-00202/_pdf

Reference36 articles.

1. 1) Pelkonen O, Turpeinen M, Hakkola J, Honkakoski P, Hukkanen J, Raunio H. Inhibition and induction of human cytochrome P450 enzymes: current status. Arch. Toxicol., 82, 667–715 (2008).

2. 2) Lin JH, Lu AY. Inhibition and induction of cytochrome P450 and the clinical implications. Clin. Pharmacokinet., 35, 361–390 (1998).

3. 3) Paine MF, Hart HL, Ludington SS, Haining RL, Rettie AE, Zeldin DC. The human intestinal cytochrome P450 “pie”. Drug Metab. Dispos., 34, 880–886 (2006).

4. 4) Zhou S-F. Polymorphism of human cytochrome P450 2D6 and its clinical significance. Clin. Pharmacokinet., 48, 761–804 (2009).

5. 5) Meloche M, Khazaka M, Kassem I, Barhdadi A, Dubé M-P, de Denus S. CYP2D6 polymorphism and its impact on the clinical response to metoprolol: a systematic review and meta-analysis. Br. J. Clin. Pharmacol., 86, 1015–1033 (2020).

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