Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

Author:

Lai Heidi T.M.12ORCID,Imamura Fumiaki3,Korat Andres V. Ardisson45,Murphy Rachel A.6,Tintle Nathan78,Bassett Julie K.9,Chen Jiaying10,Kröger Janine11,Chien Kuo-Liong12ORCID,Senn Mackenzie13,Wood Alexis C.13,Forouhi Nita G.3ORCID,Schulze Matthias B.111415ORCID,Harris William S.816,Vasan Ramachandran S.1718,Hu Frank45,Giles Graham G.91920,Hodge Allison9,Djousse Luc21,Brouwer Ingeborg A.22,Qian Frank23,Sun Qi45,Wu Jason H.Y.24,Marklund Matti12425,Lemaitre Rozenn N.26,Siscovick David S.27,Fretts Amanda M.28,Shadyab Aladdin H.29,Manson JoAnn E.3031,Howard Barbara V.32,Robinson Jennifer G.33,Wallace Robert B.33,Wareham Nick J.3,Chen Yii-Der Ida34,Rotter Jerome I.34,Tsai Michael Y.35ORCID,Micha Renata1,Mozaffarian Dariush1,

Affiliation:

1. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA

2. Department of Primary Care and Public Health, Imperial College London, London, U.K.

3. MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.

4. Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA

5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

6. School of Population & Public Health, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada

7. Department of Mathematics and Statistics, Dordt University, Sioux Center, IA

8. Fatty Acid Research Institute, Sioux Falls, SD

9. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia

10. Division of Aging, Brigham and Women's Hospital, Boston, MA

11. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

12. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Republic of China

13. U.S. Department of Agriculture/Agriculture Research Service Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX

14. German Center for Diabetes Research (DZD), Neuherberg, Germany

15. Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

16. Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD

17. Boston University School of Medicine, Boston, MA

18. The Framingham Heart Study, Framingham, MA

19. Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia

20. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia

21. Divisions of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

22. Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands

23. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA

24. The George Institute for Global Health, the Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia

25. Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden

26. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA

27. The New York Academy of Medicine, New York, NY

28. Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington School of Public Health, Seattle, WA

29. Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA

30. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

31. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA

32. Georgetown University Medical Center, Georgetown University, Hyattsville, MD

33. The University of Iowa, Iowa City, IA

34. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA

35. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN

Abstract

OBJECTIVE Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged ≥18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics. RESULTS During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94–1.25); cis/trans-18:2, 0.89 (0.73–1.07); and trans/cis-18:2, 0.87 (0.73–1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67–0.99], 0.86 [0.75–0.99], and 0.84 [0.74–0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P ≥ 0.1). CONCLUSIONS Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference37 articles.

1. International Diabetes Federation . IDF Diabetes Atlas. Ninth Edition, 2019. Accessed 13 January 2020. Available from https://diabetesatlas.org/atlas/ninth-edition/

2. Heart Disease and Stroke Statistics-2020 Update: a report from the American Heart Association;Virani;Circulation,2020

3. Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: a pooled analysis of prospective cohort studies;Imamura;PLoS Med,2018

4. Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study;Micha;Am J Clin Nutr,2010

5. U.S. Food and Drug Administration . Final Determination Regarding Partially Hydrogenated Oils (Removing Trans Fat), 2018. Accessed 19 December 2019. Available from https://www.fda.gov/food/food-additives-petitions/final- determination-regarding-partially-hydrogenated- oils-removing-trans-fat

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3