Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Author:

Zhang Fuxue12,Xia Bozhang13,Sun Jiabei4,Wang Yufei13,Wang Jinjin13,Xu Fengfei13,Chen Junge15,Lu Mei16,Yao Xin7,Timashev Peter8,Zhang Yuanyuan8,Chen Meiwan9,Che Jing3,Li Fangzhou13ORCID,Liang Xing-Jie13ORCID

Affiliation:

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China

2. Sino-Danish Center for Education and Research, Sino-Danish College of University of Chinese Academy of Sciences, Beijing 100049, China

3. School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

4. China National Institutes for Food and Drug Control, Beijing 102629, China

5. Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, Beijing 100083, China

6. Advanced Research Institute of Multidisciplinary Science, School of Life Science, School of Medical Technology (Institute of Engineering Medicine), Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China

7. School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

8. Laboratory of Clinical Smart Nanotechnologies, Institute for Regenerative Medicine, Sechenov University, Moscow, Russia

9. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China

Abstract

Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.

Funder

Science and Technology Development Fund

Beijing-Tianjin-Hebei Basic Research Cooperation Project

NSFC International Collaboration Key Project

National Natural Science Foundation of China

National Basic Research Program of China

Beijing Municipal Natural Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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