Computational Biomechanics of Human Red Blood Cells in Hematological Disorders-Reference-Cited by-同舟云学术

Computational Biomechanics of Human Red Blood Cells in Hematological Disorders

Published:2017-01-19 Issue:2 Volume:139 Page:
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Li Xuejin¹,Li He²,Chang Hung-Yu²,Lykotrafitis George³⁴,Em Karniadakis George⁵

Affiliation:

1. Division of Applied Mathematics, Brown University, Providence, RI 02912 e-mail:

2. Division of Applied Mathematics, Brown University, Providence, RI 02912

3. Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269;

4. Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269

5. Fellow ASME Division of Applied Mathematics, Brown University, Providence, RI 02912 e-mail:

Abstract

We review recent advances in multiscale modeling of the biomechanical characteristics of red blood cells (RBCs) in hematological diseases, and their relevance to the structure and dynamics of defective RBCs. We highlight examples of successful simulations of blood disorders including malaria and other hereditary disorders, such as sickle-cell anemia, spherocytosis, and elliptocytosis.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

http://asmedigitalcollection.asme.org/biomechanical/article-pdf/doi/10.1115/1.4035120/5986864/bio_139_02_021008.pdf

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