Nucleus Implant Parameters Significantly Change the Compressive Stiffness of the Human Lumbar Intervertebral Disc

Author:

Joshi Abhijeet1,Mehta Samir2,Vresilovic Edward3,Karduna Andrew4,Marcolongo Michele1

Affiliation:

1. Department of Materials Science and Engineering, Drexel University, Philadelphia PA 19104

2. Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia PA 19104

3. Department of Biomedical Engineering, Drexel University, Philadelphia PA 19104

4. Department of Human Physiology, University of Oregon, Eugene OR 97403

Abstract

Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

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