Tristan Garcia holds that what makes something some thing is its resistance to reductionism, the attempt to explain it in terms of its constituents and relations to other things. For Garcia, something just is the differentiation between those things that constitute it and the things that it helps constitute. Tristan Garcia and the Dialectics of Persistence situates Garcia’s systematic unfolding of this idea via both classical thinkers such as Aristotle, Hegel, Heidegger, and Kant as well as modern and contemporary luminaries in analytic and continental philosophy such as A.J. Ayer, Alain Badiou, Jacque Derrida, Graham Harman, Paul Livingston, John McDowell, W.V.O. Quine, and Graham Priest. The metaphysics, differential ontology, and militant anti-reductionism from Book I of Form and Object are first charitably evaluated by the way Garcia dialectically moves through a series of seemingly incompatible oppositions concerning: substance and process, analysis and dialectic, simple and whole, and discovery and creation. After explicating Garcia’s general ontology, some of the regional ontologies of Book II, those involving intensity (events, time, life, goodness, truth, and beauty) and Garcia’s own tragic aporetic dialectics (gender, adolescence, and death), are presented. Tristan Garcia and the Dialectics of Persistence bridges analytic and continental philosophy and is moreover accessible to devotes of both traditions. The marriage of analytic and continental philosophy gives rise to original argumentation, including a new understanding of the process philosophical route to metaphysical holism, a new enclosure paradox concerning metaphysical explanation, and a new argument for the existence of an empty set.