The protein corona effect for targeted drug delivery

Author:

Caracciolo Giulio1

Affiliation:

1. Department of Molecular Medicine, ‘‘Sapienza’’ University of Rome, Rome, Italy

Abstract

At present, ligand binding to nanoparticle surface is the most widespread strategy for targeting specific tissues by a receptor-mediated mechanism. However, the nanoparticles are immediately covered by a protein-rich layer when administrated in vivo, the so-called “protein corona”, with the immediate consequence that the ligand-receptor recognition may be obscured. It is not the nanoparticle-bulk composition or surface functionalization but rather the identity, arrangement and residence time of the proteins of the corona that determine the nanoparticle bioidentity, and this is an emerging concept available for use to target specific cell types in a controlled manner. An in-depth understanding of the relationship between surface properties of nanoparticles and composition of the “protein corona” is a fundamental step toward the design of nanoparticles that, once in the blood, become covered by specific proteins able to deliver them at the right site of action and promote efficient cell internalization. This “protein corona effect” is a formidable challenge that could lead to a complete renewal of the current strategies of targeted drug delivery.

Publisher

Thomas Telford Ltd.

Subject

General Engineering,Biomaterials

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3