Blood compatibility assessments of novel electrospun PVA/egg white nanocomposite membrane

Abstract

In this study, a novel electrospun wound dressing based on polyvinyl alcohol (PVA) incorporated with egg white was fabricated. The fabricated scaffold was characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy (FTIR) and contact angle measurement. Further, the coagulation assays were used to investigate the blood compatibility of the developed nanocomposites. The prepared PVA/egg white nanofibers exhibited reduced fiber and pore diameter in comparison to pristine PVA. The FTIR spectrum revealed the interaction between the PVA and egg white by the formation of the new characteristic peaks. Further, the wettability of the prepared nanocomposites was found to be increased with the mean contact angle of 54 ± 1·62°, indicating enhanced hydrophilic nature compared to pristine PVA (62 ± 1·19°). The coagulation assay results revealed that the prepared PVA/egg white nanocomposites showed delayed blood clotting, indicating better blood compatibility. Moreover, the hemolytic index of prepared PVA/egg white nanocomposites (0·94%) was observed to be low compared to pristine PVA (1·5%), suggesting its enhanced safety to red blood cells. Hence, the electrospun PVA/egg white nanocomposites exhibited better physicochemical properties and enhanced blood compatibility properties, which might serve as a valuable candidate for chronic wound healing applications.