Enhanced Effects of Combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and Interleukin-18 on the Production of Tumour Necrosis Factor-α and Interferon-γ in Human Peripheral Blood Mononuclear Cells-Reference-Cited by-同舟云学术

Enhanced Effects of Combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and Interleukin-18 on the Production of Tumour Necrosis Factor-α and Interferon-γ in Human Peripheral Blood Mononuclear Cells

Published:2004-02 Issue:1 Volume:32 Page:25-32
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Tamura R¹²,Takahashi HK²,Xue D¹,Kubo S¹²,Saito S¹,Nishibori M²,Iwagaki H¹,Tanaka N¹

Affiliation:

1. Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

2. Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

Abstract

Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-a and interferon-g. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/147323000403200104

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