Enhanced Expression of Inducible Nitric Oxide Synthase by Juzen-Taiho-To in LPS-Activated RAW264.7 Cells, a Murine Macrophage Cell Line-Reference-Cited by-同舟云学术

Enhanced Expression of Inducible Nitric Oxide Synthase by Juzen-Taiho-To in LPS-Activated RAW264.7 Cells, a Murine Macrophage Cell Line

Published:2000-01 Issue:02 Volume:28 Page:217-226
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Kawamata Hiroshi¹,Ochiai Hiroshi²,Mantani Naoki¹,Terasawa Katsutoshi¹

Affiliation:

1. Departments of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2,630, Toyama 930-0194, Japan

2. Human Science, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2,630, Toyama 930-0194, Japan

Abstract

We have investigated the effect of Juzen-taiho-to (TJ-48) on inducible NO synthase (iNOS) expression and nitric oxide (NO) production in RAW264.7 cells, a murine macrophage cell line. TJ-48-lipopolysaccharide (LPS) combination induced iNOS mRNA expression earlier, stronger and remained longer that paralleled but with a higher NO production compared to LPS stimulation. TJ-48 itself showed no inducible effect either no NO production or iNOS mRNA expression. This phenomenon could be considered to contribute, at least in part, to the beneficial effects of TJ-48 through the iNOS-mediated activation of biodefense mechanism.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X0000026X

Reference22 articles.

1. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

2. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

3. Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

4. Effect of a kanpo medicine, zyuzentaihotô, on the immune reactivity of tumor-bearing mice

5. Antitumor activities and tumor necrosis factor producibility of traditional Chinese medicines and crude drugs

Cited by 27 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Yuja Juice and Concentrate Enhance Immunomodulating Effects via Increasing Immune-Related Cytokines in RAW264.7 Cells and Mouse Splenocytes;Journal of Medicinal Food;2023-07-01

2. Anti-inflammatory Effect of Distylium racemosum leaf Biorenovate Extract in LPS-stimulated RAW 264.7 Macrophages Cells;Journal of Applied Biological Chemistry;2021-12-31

3. Black Ginseng Extract Attenuates TNF-ɑ-Induced Inflammation via Downregulation of NF-κB Signaling in Human Keratinocytes;Journal of the Korean Society of Food Science and Nutrition;2021-10-31

4. Anti-inflammatory and anti-Helicobacter effects of the Aralia elata hot-water extract;Korean Journal of Food Preservation;2021-04

5. Skin-Related Properties and Constituents from the Aerial Parts Extract of Persicaria senticosa;Oxidative Medicine and Cellular Longevity;2020-12-19