Is the Application of Prostaglandin E1 Effective for the Treatment of Sudden Hearing Loss? An Evidence-based Meta-analysis-Reference-Cited by-同舟云学术

Is the Application of Prostaglandin E1 Effective for the Treatment of Sudden Hearing Loss? An Evidence-based Meta-analysis

Published:2008-05 Issue:3 Volume:36 Page:467-470
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Zhuo Xian-Lu¹,Wang Yan²,Zhuo Wen-Lei³,Zhang Xue-Yuan¹

Affiliation:

1. Department of Otolaryngology, Southwest Hospital, Chongqing, China

2. Institute of Respiratory Diseases, Xinqiao Hospital, Chongqing, China

3. Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China

Abstract

Microvascular dysfunction in the cochlea has been considered the major cause of sudden hearing loss (SHL). For some time, prostaglandin E1 (PGE1), an effective vasodilator, has been used to treat patients with SHL, however the benefits of this therapy remain unclear. The present study assessed the efficacy of PGE1 on SHL via a quantitative meta-analysis of 13 randomized controlled studies. The pooled odds ratio was 1.95 (95% confidence interval: 1.53, 2.50) and the test for overall effect ( Z-value) was 5.31 ( P < 0.00001), suggesting that PGE1 is an effective and promising strategy for the treatment of SHL.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/147323000803600310

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