Comparison of Microscale Ultracentrifugation and Equilibrium Dialysis for the Determination of the Unbound Fraction of Theophylline in Human Serum-Reference-Cited by-同舟云学术

Comparison of Microscale Ultracentrifugation and Equilibrium Dialysis for the Determination of the Unbound Fraction of Theophylline in Human Serum

Published:1989-03 Issue:2 Volume:26 Page:185-188
ISSN:0004-5632
Container-title:Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
language:en
Short-container-title:Ann Clin Biochem

Author:

McKenzie K¹,Watson I D¹,Stewart M J¹

Affiliation:

1. Department of Biochemistry, Royal Infirmary, Glasgow G4 0SF, UK

Abstract

A microscale ultracentrifugation procedure for the measurement of free theophylline in serum is described and evaluated by comparison with an equilibrium dialysis method. Provided an ultracentrifuge is available, micro-ultracentrifugation is a simple, cost-effective technique for the routine determination of free drug fractions.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/000456328902600217

Reference14 articles.

1. Determinants of the plasma protein binding of theophylline in health.

2. Free and total plasma theophylline concentrations in chronic airflow obstruction.

3. The ex vivo plasma protein binding of theophylline in renal disease.

4. Free Drug Concentration Monitoring in Clinical Practice

5. Micro-Scale Ultracentrifugation as an Alternative to Ultrafiltration for the Determination of the Unbound Fraction of Phenytoin in Human Serum

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