Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

Author:

Staessens S1ORCID,Fitzgerald S2,Andersson T34,Clarençon F5,Denorme F1,Gounis MJ6,Hacke W7,Liebeskind DS8,Szikora I9,van Es ACGM10,Brinjikji W11,Doyle KM2,De Meyer SF1

Affiliation:

1. Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium

2. CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland

3. Department of Medical Imaging, AZ Groeninge, Kortrijk, Belgium

4. Department of Neuroradiology, Karolinska University Hospital and Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

5. Department of Neuroradiology, Pitié-Salpêtrière Hospital, APHP, Paris, France

6. Division of Neuroimaging and Intervention and New England Center for Stroke Research, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA

7. Department of Neurology, University Hospital Heidelberg, Ruprecht-Karls University, Heidelberg, Germany

8. Neurovascular Imaging Research Core and UCLA Stroke Center, University of California, Los Angeles, CA, USA

9. Department of Neuroradiology, National Institute of Neurosciences, Budapest, Hungary

10. Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center (EMC), Rotterdam, The Netherlands

11. Department of Radiology, Mayo Clinic, Rochester, MN, USA

Abstract

The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus characteristics and composition could play an important role in ongoing efforts to improve acute ischemic stroke therapy. An increasing number of centers are collecting stroke thrombi. This paper aims at providing guiding information on thrombus handling, procedures, and analysis in order to facilitate and standardize this emerging research field.

Publisher

SAGE Publications

Subject

Neurology

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