Some Characteristics of Collagenase Activity in Gingival Crevicular Fluid and Its Relationship to Gingival Diseases in Humans-Reference-Cited by-同舟云学术

Some Characteristics of Collagenase Activity in Gingival Crevicular Fluid and Its Relationship to Gingival Diseases in Humans

Published:1976-11 Issue:6 Volume:55 Page:1049-1057
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Golub Lorne M.¹,Siegel Kenneth¹,Ramamurthy N.S.¹,Mandel Irwin D.¹

Affiliation:

1. School of Dental Medicine, State University of New York, Stony Brook, New York 11794, USA, Columbia University School of Dental and Oral Surgery, New York, New York 10032

Abstract

Collagenase activity in human gingival fluid was measured using a radioactive collagen fibril assay. The activity was positively correlated with the severity of gingival disease. The fluid collagenase seemed to be controlled by α2-macroglobulin, based on its activation by NaSCN, and to be present solely in the extracellular fraction. Examination of the collagen breakdown products by acrylamide gel electrophoresis indicated that the fluid collagenase was of tissue rather than bacterial origin.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345760550060701

Reference40 articles.

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2. The Origin of Collagenase in Periodontal Tissues of Man

3. A specific collagenase from rabbit fibroblasts in monolayer culture

4. Human Granulocyte Collagenase

5. Collagenase Production by Lymphokine-Activated Macrophages

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