An Assessment of Bone Fluoride and Osteosarcoma-Reference-Cited by-同舟云学术

An Assessment of Bone Fluoride and Osteosarcoma

Published:2011-07-28 Issue:10 Volume:90 Page:1171-1176
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Kim F.M.¹,Hayes C.²,Williams P.L.³,Whitford G.M.⁴,Joshipura K.J.⁵,Hoover R.N.⁶,Douglass C.W.⁷⁸,Gebhardt M.C.,Scarborough M.T.,Gitelis S.,Eckardt J.J.,Neff J.R.,Joyce M.J.,Malawer M.,McGuire M.,Anderson H.C.,

Affiliation:

1. At the time the research was conducted, affiliated with Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, and Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA

2. Frances Stern Nutrition Center, Tufts Medical Center, Boston, MA, USA

3. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA

4. Department of Oral Biology Medical College of Georgia School of Dentistry, Augusta, GA, USA

5. Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, San Juan, PR

6. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA

7. Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA

8. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

Abstract

The association between fluoride and risk for osteosarcoma is controversial. The purpose of this study was to determine if bone fluoride levels are higher in individuals with osteosarcoma. Incident cases of osteosarcoma (N = 137) and tumor controls (N = 51) were identified by orthopedic physicians, and segments of tumor-adjacent bone and iliac crest bone were analyzed for fluoride content. Logistic regression adjusted for age and sex and potential confounders of osteosarcoma was used to estimate odds ratios (OR) and 95% confidence intervals (CI). There was no significant difference in bone fluoride levels between cases and controls. The OR adjusted for age, gender, and a history of broken bones was 1.33 (95% CI: 0.56-3.15). No significant association between bone fluoride levels and osteosarcoma risk was detected in our case-control study, based on controls with other tumor diagnoses.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/0022034511418828

Reference30 articles.

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2. FLUORIDATION OF WATER AND CANCER MORTALITY IN THE U.S.A.

3. Fluoride Concentrations in Human and Rat Bone

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