Taste Genes Associated with Dental Caries-Reference-Cited by-同舟云学术

Taste Genes Associated with Dental Caries

Published:2010-09-21 Issue:11 Volume:89 Page:1198-1202
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Wendell S.¹²,Wang X.²,Brown M.²,Cooper M.E.²,DeSensi R.S.²,Weyant R.J.¹³,Crout R.¹⁴,McNeil D.W.¹⁵,Marazita M.L.¹²⁶

Affiliation:

1. Center for Oral Health Research in Appalachia, University of Pittsburgh, PA, and West Virginia University, Morgantown, WV, USA

2. Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Suite 500 Bridgeside Point, 100 Technology Dr., Pittsburgh, PA 15219, USA

3. Department of Dental Public Health and Information Management, School of Dental Medicine, University of Pittsburgh, PA, USA

4. Department of Periodontics, School of Dentistry, West Virginia University, Morgantown, WV, USA

5. Dental Practice and Rural Health, West Virginia University, Morgantown, WV, USA

6. Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, USA

Abstract

Dental caries is influenced by a complex interplay of genetic and environmental factors, including dietary habits. Previous reports have characterized the influence of genetic variation on taste preferences and dietary habits. We therefore hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection. Families were recruited by the Center for Oral Health Research in Appalachia (COHRA) for collection of biological samples, demographic data, and clinical assessment of oral health, including caries scores. Multiple single-nucleotide polymorphism (SNP) assays for each gene were performed and analyzed by transmission disequilibrium test (TDT) analysis (FBAT software) for three dentition groups: primary, mixed, and permanent. Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/0022034510381502

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