Effect of Sugar Analogues on Growth, Sugar Utilization, and Acid Production by Streptococcus mutans-Reference-Cited by-同舟云学术

Effect of Sugar Analogues on Growth, Sugar Utilization, and Acid Production by Streptococcus mutans

Published:1975-05 Issue:3 Volume:54 Page:433-440
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Schachtele Charles F.¹,Leung Woon-Lam S.¹

Affiliation:

1. Microbiology Research Laboratories, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA

Abstract

Studies on the effect of various structural analogues of glucose of phosphoenolpyruvate (PEP)-dependent sugar transport in Streptococcus mutans showed that sugars with alterations at carbon 2 were markedly inhibitory. Low concentrations of the non-fermentable analogue D -2-deoxyglucose (2-deoxyG) blocked the growth of S mutans in broth media containing various fermentable sugars. Acid production by S mutans from. both exogenous glucose and intracellular storage polysaccharide was inhibited by 2-deoxyG. The analogue is bacteriostatic, and large quantities of intracellular 2-deoxyG-6-PO4 accumulate during exposure of S mutans to the sugar.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345750540030301

Reference25 articles.

1. Phosphoenolpyruvate-Dependent Glucose Transport in Oral Streptococci

2. Effect of Sugar Analogues on Growth, Sugar Utilization, and Acid Production by Streptococcus mutans

3. Relationship Between Sugar Structure and Competition for the Sugar Transport System in Bakers' Yeast

4. Studies on the Uptake of Hexose Phosphates

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