Screening of Sugars Inhibitory against Sucrose-dependent Synthesis and Adherence of Insoluble Glucan and Acid Production by Streptococcus mutans-Reference-Cited by-同舟云学术

Screening of Sugars Inhibitory against Sucrose-dependent Synthesis and Adherence of Insoluble Glucan and Acid Production by Streptococcus mutans

Published:1984-11 Issue:11 Volume:63 Page:1293-1297
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Imai S.¹,Takeuchi K.¹,Shibata K.¹,Yoshikawa S.²,Kitahata S.²,Okada S.²,Araya S.¹,Nisizawa T.¹

Affiliation:

1. Department of Dental Research, National Institute of Health, 2-10-35, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

2. Department of Biochemistry, Osaka Municipal Technical Research Institute, 2-1-1, Oogimachi, Kita-ku, Osaka 530, Japan

Abstract

Various sucrose derivatives and a sucrose analogue were enzymatically synthesized on the assumption that structural similarities of the sugars to sucrose would endow them with an ability to inhibit the cariogenicity of sucrose. The effect of these sugars on sucrose-dependent synthesis and adherence of insoluble glucan and on acid fermentation of sucrose by Streptococcus mutans was examined in vitro. Although none of them inhibited the acid fermentation, several sugars not only inhibited the synthesis and adherence of insoluble glucan, but were themselves only slightly fermented as well.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345840630110801

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