Guidelines of the International Headache Society for controlled trials of preventive treatment of chronic migraine in adults

Author:

Tassorelli Cristina12ORCID,Diener Hans-Christoph3ORCID,Dodick David W4ORCID,Silberstein Stephen D5,Lipton Richard B6,Ashina Messoud7,Becker Werner J89,Ferrari Michel D10,Goadsby Peter J11ORCID,Pozo-Rosich Patricia1213,Wang Shuu-Jiun14,

Affiliation:

1. Headache Science Center, C. Mondino Foundation, Pavia, Italy

2. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

3. Department of Neurology, University Hospital Essen, Essen, Germany

4. Department of Neurology, Mayo Clinic, Phoenix, AZ, USA

5. Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA

6. Montefiore Headache Center, Department of Neurology and Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA

7. Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark

8. Dept of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

9. Hotchkiss Brain Institute, Calgary, Alberta, Canada

10. Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands

11. National Institute for Health Research-Wellcome Trust King’s Clinical Research Facility, King’s College Hospital, London, England

12. Headache Research Group, VHIR, Universitat Autònoma de Barcelona, Barcelona Spain

13. Neurology Department, Hospital Vall d’Hebron, Barcelona, Spain

14. Neurological Institute, Taipei Veterans General Hospital and Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan

Abstract

Background Quality clinical trials form an essential part of the evidence base for the treatment of headache disorders. In 1991, the International Headache Society Clinical Trials Standing Committee developed and published the first edition of the Guidelines for Controlled Trials of Drugs in Migraine. In 2008, the Committee published the first specific guidelines on chronic migraine. Subsequent advances in drug, device, and biologicals development, as well as novel trial designs, have created a need for a revision of the chronic migraine guidelines. Objective The present update is intended to optimize the design of controlled trials of preventive treatment of chronic migraine in adults, and its recommendations do not apply to trials in children or adolescents.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Medicine

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