Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing-Reference-Cited by-同舟云学术

Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing

Published:2010-03-19 Issue:6 Volume:61 Page:567-573
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Fouad Hanan H.¹,Al-Dera Husain²,Bakhoum Sameh W.³,Rashed Laila A.¹,Sayed Rehab H.¹,Rateb Moshira A.⁴,Haidara Mohamed A.⁵,Soskic Sanja⁶,Isenovic Esma R.⁶

Affiliation:

1. Department of Medical Biochemistry, Kasr Al-Aini Faculty of Medicine, Cairo University, Giza, Egypt

2. Department of Physiology, College of Medicine, King Saud bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia

3. Department of Cardiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Giza, Egypt

4. Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Giza, Egypt

5. Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia,

6. Department for Molecular Genetics and Radiobiology, Vinča Institute, University of Belgrade, Belgrade, Serbia

Abstract

We determined the serum levels of soluble CD40 ligand (sCD40L) in patients with chronic coronary artery disease (CAD) and acute coronary syndrome (ACS). Patients with unstable angina (UA) and myocardial infarction (MI) showed significantly higher levels (P < .001) of sCD40L compared with patients with stable angina (SA) and controls; particularly, high levels occurred in patients with UA (UA: 9.23 ± 2.92, MI: 7.38 ± 1.05, SA: 4.42 ± 1.08; control: 4.01 ± 0.87 ng/mL). There was no significant difference in sCD40L levels between patients with UA and MI or between patients with SA and controls. Levels of sCD40L did not show any significant correlation with peak creatine kinase (CK), CK-MB isoenzyme activity in patients with MI, troponin T serum levels in patients with UA or with culprit vessel (CV) complexity score (CVCS), type of CV lesion, or vessel score in patients with UA or MI. These results suggest that CD40L plays a pathogenic role in triggering ACS.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003319709356785

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