Levels of Soluble TREM-Like Transcript 1 in Patients Presenting to the Emergency Department With Chest Pain

Abstract

Objective: Recent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary syndrome (ACS). Methods: Levels of sTLT-1 were determined by enzyme-linked immunosorbent assay on plasma from patients with potential ACS and compared with an age-matched control group with similar risk factors for cardiovascular disease. Results: Of 53 patients enrolled, 19 patients were undergoing ACS (15 unstable angina, 2 non–ST-segment elevated myocardial infarction, and 2 ST-segment elevated myocardial infarction), 5 patients were found with noncardiac chest pain, and 29 were in the control group. The mean plasma sTLT-1 values in the ACS group were 4.644 ng/mL ± 1.277 standard error of the mean (SEM), in the noncardiac chest pain group were 0.708 ng/mL ± 0.427 SEM, and in the control group were 1.007 ng/mL ± 0.098 SEM. Conclusion: A statistically significant difference exists between patients experiencing cardiogenic chest pain versus controls ( P < .05), suggesting sTLT-1 as a potential tool for understanding atherothrombosis in ACS.