A Comparative Trial of Slow-Release Aminophylline, Salbutamol and a Half Dose Combination in the Prevention of Childhood Asthma

Abstract

The effect of slow-release aminophylline, salbutamol and a half dose combination of both was compared in children with chronic asthma. Drugs were given over three consecutive 5-week periods during which patients recorded daily peak flow measurements and symptom scores. At the end of each treatment period pulmonary function tests were done. Sixteen of twenty-nine children completed the trial satisfactorily and their results have been used for analysis. The data show slow-release aminophylline and salbutamol to be equally effective and the half dose combination as effective as either drug alone. The results suggest there may be a therapeutic advantage in combining a β2 agonist with theophylline when high doses of either drug alone are not fully effective or when toxic effects occur.