1. Effects of oral theophylline and oral salbutamol in the treatment of asthma;P, Dawson K.; M, Fergusson D.;Arch Dis Child,1982
2. Dosage guidelines for slow-release aminophylline in childhood asthma;Blumenthal, I.; Berry, D.;Br J Clin Pharmacol,1980
3. A comparative trial of slow-release aminophylline, salbutamol, and a half dose combination in the prevention of childhood asthma;Blumenthal, I.;J Int Med Res,1980
4. Dosage of oral salbutamol in asthmatic children;M, Connolly N.;Arch Dis Child,1971
5. Since the major aim of our trial was to examine the hypothesis of Wilson et al.1 that when used in combination salbutamol and theophylline produced increased serum theophylline levels, measures of peak flow were collected only incidentally during the course of the trial. Therefore, we cannot comment on whether similar effects would be shown with a percentage improvement statistic. However, Blumenthal's comments appear to have missed the major point of our analysis which was not to demonstrate differences in single measures but rather differences in joint, multivariate, distribution of serum levels, peak flow rates, and pulse rates between treatment groups. The compelling aspect of the study is the way in which all three indices behave in similar ways between the two treatments rather than the results for single measures