An Analgesic Comparison of Floctafenine (Idarac) and Dihydrocodeine in Post-Operative Pain

Author:

Lipton S1,Conway M1,Akbar F Ali2

Affiliation:

1. Consultant Anaesthetist, The Centre of Pain Relief, Regional Neurosurgical Centre, Walton Hospital, Liverpool

2. Medical Division, Roussel Laboratories Limited, Wembley Park, Middlesex, England

Abstract

A double-blind crossover study comparing floctafenine 200 mg, a new analgesic drug, and dihydrocodeine 60 mg, was performed on 72 patients suffering from post-operative pain. Degree of pain relief by floctafenine was similar to that of dihydrocodeine but the relief afforded by the former was of longer duration. Side-effects associated with dihydrocodeine were statistically higher than those associated with floctafenine. Floctafenine was demonstrated to be an effective analgesic with an insignificant incidence of untoward side-effects.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pharmacodynamics of Orally Administered Sustained- release Hydromorphone in Humans;Anesthesiology;2001-01-01

2. Single dose oral dihydrocodeine for acute postoperative pain;Cochrane Database of Systematic Reviews;2000-10-23

3. Floctafenine: a Valid Alternative in Patients with Adverse Reactions to Nonsteroidal Anti-inflammatory Drugs;Annals of Allergy, Asthma & Immunology;1997-01

4. Pharmakologie des Dihydrocodeins;Chronischer Schmerz — Therapiekonzepte;1989

5. The Metabolism of Floctafenin in Man and Rodents;The Journal of Clinical Pharmacology;1979-01

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