Prostaglandin E1 for Renal Papillary Necrosis in a Patient with Diabetes Mellitus

Author:

Abe K1,Ozono Y1,Miyazaki M1,Fvrusu A1,Shioshita K1,Sasaki O1,Tsukasaki S1,Harada T2,Kohno S1

Affiliation:

1. Second Department of Internal Medicine and, Nagasaki University School of Medicine, Nagasaki, Japan

2. Division of Renal Care Unit, Nagasaki University School of Medicine, Nagasaki, Japan

Abstract

We report a case of renal papillary necrosis with diabetes mellitus which was treated with prostaglandin E1. An intravenous infusion of 40 mg/day prostaglandin E1 was given for 14 days in an attempt to improve renal circulation. Treatment resulted in an improved creatinine clearance, renal plasma flow and renogram, and proteinuria was decreased. The administration of prostaglandin E1 produced an improvement in renal haemodynamics and can be considered as a possible therapy for renal papillary necrosis in diabetic patients.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

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