Microencapsulation of cells in alginate through an electrohydrodynamic process

Author:

Gasperini L12,Maniglio D123,Migliaresi C123

Affiliation:

1. Department of Industrial Engineering, Biotech Research Center, University of Trento, Trento, Italy

2. European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Trento, Italy

3. INSTM–Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, Firenze, Italy

Abstract

The encapsulation of living cells within a semi-permeable matrix is an attractive process for transplanting nonautologous cells by limiting the interaction with the host immune system. The electrohydrodynamic process is a low-cost and high-throughput system to encapsulate cells by means of a static potential. We evaluated the use of this system for cell entrapment by assessing and then manufacturing capsules that had the best dimensions. The effect of different cell densities on the beads was determined to set up the basic parameters of the encapsulation system. The cell viability inside the beads and as a function of release time was observed for their biological response.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

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