Lipid-like Diblock Copolymer as an Additive for Improving the Blood Compatibility of Poly(lactide-co-glycolide)

Abstract

To optimize the blood biocompatibility of poly(lactide-coglycolide) (PLGA), lipid-like diblock copolymer poly(DL-lactide)-block-poly(2-methacryloyloxyethyl phosphorylcholine) (PLA-b-PMPC) was employed as a surface-modifying additive. The blends of PLGA and PLA-b-PMPC coated poly(ethylene terephthalate) membranes were prepared by dip-coating. ATR-FTIR spectroscopy showed the incorporation of phosphorylcoline groups in the blends and contact angle results indicated that the hydrophilicity of the blends improved with increasing PLA-b-PMPC content. The plasma recalcification time of polymer coating was prolonged and the amount of adherent platelets on coating surface was decreased by introducing PLA-b-PMPC. The adhesion of polymer coating on the gold electrode of quartz crystal microbalance was monitored and PLGA containing PLA-b-PMPC additives showed excellent polymer—metal adhesion. These results show that the blends of PLGA and lipid-like PLA-b-PMPC could be used as high performance biodegradable polymer coatings for blood contact medical devices.