Synthesis, Characterization and Preliminary Investigation of Blood Compatibility of Novel Epoxy-modified Polyurethane Networks

Abstract

To prepare elastomers with acceptable physical properties and good blood compatibility, polyurethane networks were synthesized via crosslinking reaction of epoxy-terminated polyurethane prepolymers (EUPs) and hexamethylene diamine. EUPs were prepared by reacting glycidol and NCO-terminated polyurethanes. All new materials were characterized by conventional spectroscopic methods and properties were evaluated and correlated to their structure. Cytotoxcicity evaluation for the films of samples based on mouse fibroblasts (L929) revealed that these elastomers posed no threat to these cells. In vitro platelet-rich plasma contact test showed reduced number of adhered platelets on the surface of the films, particularly for those with maximum crystallinity and microphase structures and high hydrophilicity. The results obtained implied the potential for the utilization of these elastomers in biomedical applications.