Biological Effects of Tissue Modulations in Wound Healing-Reference-Cited by-同舟云学术

Biological Effects of Tissue Modulations in Wound Healing

Published:1995-04 Issue:2 Volume:10 Page:85-102
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Fini M.¹,Morrone G.¹,Giardino R.¹,Ferioli G.²,Mattioli-Belmonte M.³,Amati S.³,Tietz C.³,Biagini G.³,Tappa M. M.⁴,Ricotti G.⁴

Affiliation:

1. Experimental Surgery I.O.R., Via di Barbiano 1/10, University of Bologna, 40100 Bologna, Italy

2. Institute of Histology and Embriology, Via Belmeloro 8, University of Bologna, 40100 Bologna, Italy

3. Institute of Human Morphology, Faculty of Medicine, Via P. Ranieri, University of Ancona, 60131 Ancona, Italy

4. Dermatology Clinic, L.go Cappelli 1, University of Ancona, 60100 Ancona, Italy

Abstract

The reactive and reparative capacity of injured tissue when treated with either Pulsed Electromagnetic Fields (PEMFs) or with immunomodulator drugs (Prostaglandin E2 and Thymopentin) was evaluated. A morphological and quantitative evaluation was made of the interactions and the interferences on the structural stages of tissue repair processes. When PEMFs were used the time required for new tissue to completely cover the wound was 26 days after surgery, instead of 30 days for control conditions or for treatment with PGE2 or Thymopentin. PEMFs showed accelerated healing process. Both PGE2 and Thymopentin should be considered, in association with other drugs, in an attempt to strengthen the various immunomodulative phases of the reconstitution of injured tissue.

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/088391159501000201

Reference29 articles.

1. Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing.

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3. Biology of interleukin 1

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