Expression of MMP-8 and MMP-13 Genes in the Periodontal Ligament during Tooth Movement in Rats-Reference-Cited by-同舟云学术

Expression of MMP-8 and MMP-13 Genes in the Periodontal Ligament during Tooth Movement in Rats

Published:2003-08 Issue:8 Volume:82 Page:646-651
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Takahashi I.¹²,Nishimura M.¹²,Onodera K.¹²,Bae J.-W.¹²,Mitani H.¹²,Okazaki M.¹²,Sasano Y.¹²,Mitani H.¹²

Affiliation:

1. Division of Orthodontics and Dentofacial Orthopedics,

2. Division of Molecular Biology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku Sendai, 980-8575, Japan;

Abstract

Periodontal ligament tissue is remodeled on both the tension and compression sides of moving teeth during orthodontic tooth movement. The present study was designed to clarify the hypothesis that the expression of MMP-8 and MMP-13 mRNA is promoted during the remodeling of periodontal ligament tissue in orthodontic tooth movement. We used the in situ hybridization method and semi-quantitative reverse-transcription/polymerase chain-reaction analysis to elucidate the gene expression of MMP-8 and MMP-13 mRNA. Expression of MMP-8 and MMP-13 mRNA transiently increased on both the compression and tension sides during active tooth movement in vivo. The gene expression of MMP-8 and MMP-13 was induced by tension, while compression indirectly promoted the gene expression of MMP-8 and MMP-13 through soluble factors in vitro. Thus, we concluded that the expression of MMP-8 and MMP-13 is differentially regulated by tension and compression, and plays an important role in the remodeling of the periodontal ligament.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/154405910308200815

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