Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines-Reference-Cited by-全球学者库

Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines

Published:2017-04 Issue:4 Volume:39 Page:101042831769596
ISSN:1010-4283
Container-title:Tumor Biology
language:en
Short-container-title:Tumour Biol.

Author:

Bai Haitao¹,Zhou Lili²,Wang Chun¹,Xu Xiaowei¹,Jiang Jieling¹,Qin Youwen¹,Wang Xiaorui¹,Zhao Chuxian¹,Shao Shan¹

Affiliation:

1. Department of Hematology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, China

2. Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

Abstract

In this study, we investigated whether miR-125a participated in the resistance of the leukemia cell lines to the chemotherapeutic agent daunorubicin. Higher expression of miR-125a is correlated with lower treatment response and shorter overall survival in acute leukemia patients. Overexpression of miR-125a induced drug resistance in HL-60, K562, and THP-1cell lines through reducing apoptosis. We also showed that miR-125a mediated daunorubicin resistance in leukemia cell lines through the decrease of GRK2 and Puma which were proved to be direct targets of miR-125a. This study may provide novel therapeutic targets for therapy and improve predictions of therapeutic responses in leukemia to daunorubicin.

Publisher

IOS Press

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1010428317695964

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