Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation-Reference-Cited by-同舟云学术

Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

Published:2008-10-20 Issue:11 Volume:205 Page:2499-2506
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Bousquet Marina¹,Quelen Cathy¹,Rosati Roberto²,Mansat-De Mas Véronique¹³⁴,La Starza Roberta²,Bastard Christian⁵,Lippert Eric⁶,Talmant Pascaline⁷,Lafage-Pochitaloff Marina⁸,Leroux Dominique⁹,Gervais Carine¹⁰,Viguié Franck¹¹,Lai Jean-Luc¹²,Terre Christine¹³,Beverlo Berna¹⁴,Sambani Costantina¹⁵,Hagemeijer Anne¹⁶,Marynen Peter¹⁶,Delsol Georges¹³⁴,Dastugue Nicole¹⁴,Mecucci Cristina²,Brousset Pierre¹³⁴

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale, U563, Centre de Physiopathologie de Toulouse-Purpan, 31300 Toulouse, France

2. Cytogenetic and Molecular Genetic Unit, Division of Hematology, IBiT Foundation, University of Perugia, 06123 Perugia, Italy

3. Université Paul Sabatier, 31062 Toulouse, France

4. Département de Pathologie et d'Hématologie Biologique, Centre Hospitalier Universitaire Purpan, 31059 Toulouse, France

5. Département de Génétique, Centre Henri Becquerel, 76038 Rouen, France

6. Laboratoire d'Hématologie-Cytogénétique, Hôpital Haut-Lévêque, 33604 Pessac, France

7. Laboratoire de Cytogénétique Hématologique, Hôtel Dieu, 44035 Nantes, France

8. Laboratoire de Cytogénétique Hématologique, Centre Hospitalier Universitaire La Timone, 13005 Marseille, France

9. Laboratoire d'Hématologie Cellulaire et Moléculaire, Site Etablissement Français du Sang–Centre Hospitalier Universitaire, 38043 Grenoble, France

10. Laboratoire d'Hématologie Cellulaire et Cytogénétique, Centre Hospitalier Universitaire Haute-Pierre, 67098 Strasbourg, France

11. Laboratoire de Cytogénétique et d'Hématologie Biologique, Hôtel Dieu, 75181 Paris, France

12. Laboratoire de Génétique Médicale, Centre Hospitalier Universitaire, 59037 Lille, France

13. Laboratoire de Cytogénétique et Transfusion Sanguine, BP122, 78150 Le-Chesnay, France

14. Department of Clinical Genetics, Erasmus MC, 3000-3099 Rotterdam, Netherlands

15. Laboratory of Cytogenetics, National Centre of Scientific Research “Demokritos,” 10551 Athens, Greece

16. Department of Human Genetics and VIB, Katholieke Universiteit Leuven, 3000 Leuven, Belgium

Abstract

Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong up-regulation of miR-125b (from 6- to 90-fold). In vitro experiments revealed that miR-125b was able to interfere with primary human CD34+ cell differentiation, and also inhibited terminal (monocytic and granulocytic) differentiation in HL60 and NB4 leukemic cell lines. Therefore, miR-125b up-regulation may represent a new mechanism of myeloid cell transformation, and myeloid neoplasms carrying the t(2;11) translocation define a new clinicopathological entity.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/205/11/2499/1195025/jem_20080285.pdf

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