Fast assessment and management of chest pain patients without ST-elevation in the pre-hospital gateway (FamouS Triage): ruling out a myocardial infarction at home with the modified HEART score

Author:

Ishak Maycel1,Ali Danish2,Fokkert Marion J3,Slingerland Robbert J3,Tolsma Rudolf T4,Badings Erik5,van der Sluis Aize5,van Eenennaam Fred67,Mosterd Arend8,ten Berg Jurriën M9,van ’t Hof Arnoud WJ1

Affiliation:

1. Department of Cardiology, Isala Hospital, The Netherlands

2. Department of Cardiology, University Hospital Coventry, UK

3. Department of Clinical Chemistry, Isala Hospital, The Netherlands

4. Regional Ambulance Service IJsselland, Zwolle, The Netherlands

5. Department of Cardiology, Deventer Ziekenhuis, The Netherlands

6. The Decision Group, Amsterdam, The Netherlands

7. Erasmus School of Accounting & Assurance, Erasmus University, The Netherlands

8. Department of Cardiology, Meander Medical Centre, The Netherlands

9. Department of Cardiology, St Antonius Hospital, The Netherlands

Abstract

Background: The first study of the FamouS Triage project investigates the feasibility of ruling out a myocardial infarction in pre-hospital chest pain patients without electrocardiographic ST-segment elevation by using the modified HEART score at the patient’s home, incorporating only a single highly sensitive troponin T measurement. Methods: A venous blood sample was drawn in the ambulance from 1127 consecutive chest pain patients for measurement of the pre-hospital highly sensitive troponin T levels, in order to establish a pre-hospital HEART score (i.e. the modified HEART score) and evaluate the possibility of triage at the patient’s home. The primary endpoint was the occurrence of a major adverse cardiac event (MACE) i.e. acute myocardial infarction, percutaneous coronary intervention, coronary artery bypass grafting or death within 30 days after initial presentation. Results: Two hundred and six patients (18%) developed a MACE during 30 days of follow-up. Thirty-six per cent of the patients ( n=403) had a low modified HEART score (0–3 points) and none of them developed a MACE during follow-up. Forty-four per cent of the patients ( n=494) had an intermediate modified HEART score (4–6 points) and 18% of them developed a MACE. Twenty per cent of the patients ( n=230) had a high modified HEART score (7–10 points) of which 52% developed a MACE during follow-up. Conclusion: It seems feasible to rule out a myocardial infarction at home in chest pain patients without ST-segment elevation by using the modified HEART score. TRIAL ID: NTR4205. Dutch Trial Register [ http://www.trialregister.nl ]: trial number 4205.

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Critical Care and Intensive Care Medicine,General Medicine

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