Concurrent JAK2-Positive Myeloproliferative Disorder and Chronic Myelogenous Leukemia: A Novel Entity? A Case Report With Review of the Literature-Reference-Cited by-同舟云学术

Concurrent JAK2-Positive Myeloproliferative Disorder and Chronic Myelogenous Leukemia: A Novel Entity? A Case Report With Review of the Literature

Published:2019-01 Issue: Volume:7 Page:232470961983232
ISSN:2324-7096
Container-title:Journal of Investigative Medicine High Impact Case Reports
language:en
Short-container-title:Journal of Investigative Medicine High Impact Case Reports

Author:

Bader Gilbert¹^ORCID,Dreiling Bernard²

Affiliation:

1. University of Mississippi Medical Center, Jackson, MS, USA

2. GV Montgomery VA Medical Center, Jackson, MS, USA

Abstract

JAK2 V617F mutation and BCR-ABL translocation have been considered to be mutually exclusive. However, many cases where both hits coexisted have been reported. We have personally managed a case too. We believe this hybrid entity is underdiagnosed. Thus, we decided to shed light on this “double hit” disease to improve its diagnosis and optimize its treatment. We reviewed the English literature in PubMed since JAK2 discovery. We found 33 cases reported so far. We summarized patient characteristics and analyzed possible interactions between JAK2 and BCR-ABL clones.

Publisher

SAGE Publications

Subject

Safety Research,Safety, Risk, Reliability and Quality,Epidemiology

Link

http://journals.sagepub.com/doi/pdf/10.1177/2324709619832322

Reference32 articles.

1. Epidemiology of myeloproliferative neoplasms in the United States

2. The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders

3. JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia

4. Polycythemia associated with the JAK2V617F mutation emerged during treatment of chronic myelogenous leukemia

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4. A 68-Year-Old Man with a Cytogenetic Diagnosis of Chronic Myeloid Leukemia and Bone Marrow Findings of Philadelphia Chromosome Translocation Between the Long Arm of Chromosomes 9 and 22, Leading to the BCR-ABL1 Fusion Gene and V617F Mutation in the JAK2 Gene;American Journal of Case Reports;2023-02-03

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