Radiotherapy-Induced Skin Reactions Induce Fibrosis Mediated by TGF-β1 Cytokine-Reference-Cited by-同舟云学术

Radiotherapy-Induced Skin Reactions Induce Fibrosis Mediated by TGF-β1 Cytokine

Published:2017-04-28 Issue:2 Volume:15 Page:155932581770501
ISSN:1559-3258
Container-title:Dose-Response
language:en
Short-container-title:Dose-Response

Author:

de Andrade Cherley Borba Vieira¹²,Ramos Isalira Peroba Rezende³,de Moraes Alan César Nunes⁴,do Nascimento Ana Lúcia Rosa⁵,Salata Camila¹,Goldenberg Regina Coeli dos Santos⁶,de Carvalho Jorge José⁵,de Almeida Carlos Eduardo Veloso¹

Affiliation:

1. Radiological Sciences Laboratory, Department of Biophysics and Biometry, State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil

2. Translational Endocrinology Laboratory, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil

3. Center Structural Biology and Bio-imaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

4. Department of Biology, Federal Fluminense University, Niterói, RJ, Brazil

5. Ultrastructure Laboratory and Tissue Biology, Department of Histology and Embriology (UERJ), Rio de Janeiro, RJ, Brazil

6. Cellular and Molecular Cardiology Laboratory, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil

Abstract

Purpose: This study aimed to investigate radiation-induced lesions on the skin in an experimental animal model. Methods and Materials: Cutaneous wounds were induced in Wistar rats by 4 MeV energy electron beam irradiation, using a dose rate of 240 cGy/min, for 3 different doses (10 Gy, 40 Gy, and 60 Gy). The skin was observed 5, 10, and 25 days (D) after ionizing radiation exposition. Results: Infiltrate inflammatory process was observed in D5 and D10, for the 40 Gy and 60 Gy groups, and a progressive increase of transforming growth factor β1 is associated with this process. It could also be noted a mischaracterization of collagen fibers at the high-dose groups. Conclusion: It was observed that the lesions caused by ionizing radiation in rats were very similar to radiodermatitis in patients under radiotherapy treatment. Advances in Knowledge: This study is important to develop strategies to prevent radiation-induced skin reactions.

Publisher

SAGE Publications

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1559325817705019

Reference33 articles.

1. Skin Toxicity During Breast Irradiation: Pathophysiology and Management

2. RTOG criteria to evaluate acute skin reaction and its risk factors in patients with breast cancer submitted to radiotherapy

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