Fungal Endocarditis: An Autopsy Study

Author:

Challa Sundaram1,Prayaga Aruna Kumari1,Vemu Laxmi1,Sadasivan Jaishankar1,Jagarlapudi Murali Krishna Murthy1,Digumarti Raghunadharao1,Prabhala Rajagopal1

Affiliation:

1. Nizam's Institute of Medical Sciences, Hyderabad, India Institute of Neurological Sciences Care Hospital, Hyderabad, India

Abstract

Between 1990 and 2002, 237 hearts were examined at autopsy, including 16 with infective endocarditis; 6 showed fungal endocarditis. The preceding pathology was chronic rheumatic heart disease in 2 patients, one of whom had undergone double valve replacement, 2 patients had been treated for acute lymphoblastic leukemia, and one had protein-energy malnutrition. The underlying cause was unknown in one case. The organisms isolated were Aspergillus in 3 patients, Zygomycota in 1, Candida in 1, and both Candida tropicalis and Aspergillus in 1 patient. Immunosuppressed states are a cause of fungal endocarditis in India, although chronic rheumatic heart disease is the preceding pathology in the majority of patients.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,General Medicine,Surgery

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1. Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management;Clinical Microbiology Reviews;2023-09-21

2. Mucormycosis: Pathogenesis and Pathology;Current Fungal Infection Reports;2019-01-19

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4. Acute Ischemic or Hemorrhagic Stroke Syndromes;Fungal Infections of the Central Nervous System;2019

5. Pathogenesis and Pathology of Invasive Aspergillosis;Current Fungal Infection Reports;2018-01-23

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